Summary of a novel, three-component regulatory model for uridine diphosphate glucuronyltransferase.
نویسندگان
چکیده
Macksad, A., Schoental, R. & Coady, A. (1970) J. Kwt. Med. Assoc. 4, 297-299 Salem, S. N. (1967) Recent Ado. Gastroenterol. 3 , 90-93 Schoental, R. (1968) Zsr. J. Med. Sci. 4, 1133-1145 Schoental, R. (1975) Cancer Res. 35, 2020-2024 Schoental, R., Fowler, E. M. & Coady, A. (1970) Cancer Res. 30, 2127-2131 Watt, J. M. & Breyer-Brandwijk, M. G. (1962) The MedicinalandPoisonous Plants of Southern and Eastern Africa, 2nd edn., Livingstone, Edinburgh
منابع مشابه
Membrane Dependence of Uridine Diphosphate Glucuronyltransferase: Effect of the Membrane on Kinetic Properties
s of Communications Meeting of the Biochemical Society Pharmacological Biochemistry Group, St. Mary3 Hospital Medical School, London 13 September 1974 GLUCURONIDATION MECHANISMS : a Colloquium organized by P. T. Nowell (Liverpool) Membrane Dependence of Uridine Diphosphate Glucuronyltransferase : Effect of the Membrane on Kinetic Properties DAVID ZAKIM and DONALD A. VESSEY Departments of Medici...
متن کاملStudies on the purification of rat liver uridine diphosphate glucuronyltransferase.
1. A stable, more highly purified, preparation of UDP-glucuronyltransferase was obtained than previously reported. 2. Enzyme activity towards o-aminophenyl and p-nitrophenyl was increased 43- and 46-fold respectively. 3. The final preparation contains only three staining polypeptide bands visible after sodium dodecyl sulphate/polyacrylamide-gel electrophoresis. 4. The only known major accompany...
متن کاملDevelopment of Phenobarbital-sensitive Control Mechanisms for Uridine Diphosphate Glucuronyltransferase Activity in Chick Embryo Liver
Uridine diphosphate (UDP) glucuronyltransferase activity in chick liver rises at hatching from near zero to adult levels. This rise will occur prematurely in embryo liver during organ culture. Increase in enzyme activity during organ culture differs with embryo age: in liver from 11-day old embryos it ceases at adult values; in liver from 5-day old embryos it continues to much higher-than-adult...
متن کاملThe Role of the Microsomal Membrane in Control of Uridine Diphosphate Glucuronyltransferase Activity in vitro and in vivo
for phase separationwithin thelipidphase(Phillipsetal., 1970; Shimschick & McConnel, 1973) UDP-glucose inhibited the activity of UDP-glucuronyltransferase. There was no inhibition at any temperature above 16°C. Similarly, at temperatures below that for phase separation within the lipid portion of the membrane, UDP-glucuronyltransferase was insensitive to activation by UDP-N-acetylglucosamine. I...
متن کاملPhospholipid content and activity of pure uridine diphosphate-glucuronyltransferase from rat liver.
Rat liver phospholipids were radioactively labeled in vivo before purification of UDP-glucuronyltransferase to homogeneity. The pure enzyme contained very little phospholipid (approx. 0.7 mol of phospholipid/mol of protein). The solubilization detergent Lubrol 12A9 appeared to act as a phospholipid substitute, capable of supporting UDP-glucuronyltransferase activity. Phospholipase C did not inh...
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ورودعنوان ژورنال:
- Biochemical Society transactions
دوره 4 4 شماره
صفحات -
تاریخ انتشار 1976